Clindamycin in a murine model of toxoplasmic encephalitis

Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis.

Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is hampered by severe side effects including allergic reactions and hematotoxicity. Alternative treatment reg...

Toxoplasmic Encephalitis

Local treatment of toxoplasmic retinochoroiditis with intravitreal clindamycin and dexamethasone.

PURPOSE To report the clinical outcomes of local treatment of toxoplasmic retinochoroiditis (TRC) with intravitreal injections of clindamycin and dexamethasone. METHODS STUDY POPULATION 16 eyes (16 patients) with active TRC sparing the macula and juxtapapillary area treated with intravitreal injections of clindamycin (1 mg) and dexamethasone (1 mg) without concomitant systemic antitoxoplas...

Management of toxoplasmic encephalitis in HIV-infected adults--a review.

To the Editor: Many patients in Africa present with HIV for the first time when they develop an opportunistic infection such as toxoplasmic encephalitis (TE). Optimal management of opportunistic infections such as TE is important in improving health and allowing patients to benefit from the expanding roll-out of highly active antiretroviral therapy (HAART).1-3 Possible treatment regimens for TE...

Toxoplasmic encephalitis on positron emission tomography

A 31-year-old woman presented with a 2-day history of rightsided weakness, numbness and paresthesia. She was diagnosed with acquired immunodeficiency syndrome (AIDS) 8 months before. Her most recent CD4 count was 19 cells/cmm and her viral load was 15,000 copies/mL, and she reported taking antiretroviral therapy plus prophylactic trimethoprim-sulfamethoxazole and azithromycin. Analysis of her c...